Version 5.4
Homo sapiens Gene: EXOSC5
Summary
InnateDB Gene IDBG-53029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOSC5
Gene Name exosome component 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000077348
Encoded Proteins
IDBP-53031
exosome component 5
IDBP-762110
IDBP-765747
IDBP-765132
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41386374-41397479
Strand Reverse strand
Band q13.2
Transcripts
ENST00000221233 ENSP00000221233
ENST00000593523
ENST00000593771 ENSP00000471557
ENST00000602129 ENSP00000472396
ENST00000596905 ENSP00000471002
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 39 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006364 rRNA processing
GO:0006401 RNA catabolic process
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045006 DNA deamination
GO:0051607 defense response to virus
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0000178 exosome (RNase complex)
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0035327 transcriptionally active chromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061286
View Gene Order
ENSBTAG00000016034
Not yet available
Pathways
NETPATH
REACTOME
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_25042
KSRP destabilizes mRNA pathway
REACT_20619
mRNA decay by 3' to 5' exoribonuclease pathway
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_17015
Metabolism of proteins pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_020158
HUGO
OMIM
CCDS CCDS12580
HPRD 16222
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca