InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DGCR8

Summary

InnateDB Gene

IDBG-1583.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGCR8

Gene Name

DiGeorge syndrome critical region gene 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000128191

Encoded Proteins

IDBP-1585

DiGeorge syndrome critical region gene 8

IDBP-1587

DiGeorge syndrome critical region gene 8

IDBP-292551

DiGeorge syndrome critical region gene 8

IDBP-362649

DiGeorge syndrome critical region gene 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:20080232-20111877

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000351989	ENSP00000263209
ENST00000383024	ENSP00000372488
ENST00000407755	ENSP00000384726
ENST00000457069	ENSP00000409625
ENST00000495826
ENST00000498171
ENST00000491892
ENST00000495351
ENST00000485802
ENST00000475941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0010467	gene expression
GO:0031053	primary miRNA processing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022718

View Gene Order

ENSBTAG00000019869

Not yet available

Pathways

NETPATH

REACTOME

REACT_12417

MicroRNA (miRNA) biogenesis pathway

REACT_71

Gene Expression pathway

REACT_12472

Regulatory RNA pathways pathway

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.606163 Hs.643452 Hs.732256

RefSeq

NM_001190326 NM_022720 XM_006724268

HUGO

OMIM

CCDS

CCDS13773 CCDS54501

HPRD

09913

IMGT

EMBL

GenPept

RNA Seq Atlas