InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dna2

Summary

InnateDB Gene

IDBG-158343.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dna2

Gene Name

DNA replication helicase 2 homolog (yeast)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036875

Encoded Proteins

IDBP-158347

DNA replication helicase 2 homolog (yeast)

IDBP-532944

DNA replication helicase 2 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138346:
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010]
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:62947026-62974185

Strand

Forward strand

Band

Transcripts

ENSMUST00000092462	ENSMUSP00000090119
ENSMUST00000131422	ENSMUSP00000115750
ENSMUST00000131715
ENSMUST00000129785
ENSMUST00000139212
ENSMUST00000137378

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base
GO:0017108	5'-flap endonuclease activity
GO:0043139	5'-3' DNA helicase activity
GO:0043142	single-stranded DNA-dependent ATPase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000729	DNA double-strand break processing
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006264	mitochondrial DNA replication
GO:0006284	base-excision repair
GO:0032508	DNA duplex unwinding
GO:0033567	DNA replication, Okazaki fragment processing
GO:0043137	DNA replication, removal of RNA primer
GO:0043504	mitochondrial DNA repair
GO:0045740	positive regulation of DNA replication