InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DNA2

Summary

InnateDB Gene

IDBG-76116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNA2

Gene Name

DNA replication helicase 2 homolog (yeast)

Synonyms

DNA2L; hDNA2

Species

Homo sapiens

Ensembl Gene

ENSG00000138346

Encoded Proteins

IDBP-76118

DNA replication helicase 2 homolog (yeast)

IDBP-231239

DNA replication helicase 2 homolog (yeast)

IDBP-231241

DNA replication helicase 2 homolog (yeast)

IDBP-377916

DNA replication helicase 2 homolog (yeast)

IDBP-596387

DNA replication helicase 2 homolog (yeast)

IDBP-587530

DNA replication helicase 2 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009 [PubMed 19487465]).[supplied by OMIM, Nov 2010]
This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:68414064-68472121

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000358410	ENSP00000351185
ENST00000399180	ENSP00000382133
ENST00000399179	ENSP00000382132
ENST00000440722	ENSP00000389713
ENST00000478029
ENST00000551118	ENSP00000450393
ENST00000550545
ENST00000550357	ENSP00000450014

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0004386	helicase activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base
GO:0017108	5'-flap endonuclease activity
GO:0043139	5'-3' DNA helicase activity
GO:0043142	single-stranded DNA-dependent ATPase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0000729	DNA double-strand break processing
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006264	mitochondrial DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006284	base-excision repair
GO:0032201	telomere maintenance via semi-conservative replication
GO:0032508	DNA duplex unwinding
GO:0033567	DNA replication, Okazaki fragment processing
GO:0043137	DNA replication, removal of RNA primer
GO:0043504	mitochondrial DNA repair
GO:0045740	positive regulation of DNA replication