Version 5.4
Mus musculus Gene: A1cf
Summary
InnateDB Gene IDBG-158361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A1cf
Gene Name APOBEC1 complementation factor
Synonyms 1810073H04Rik; Acf; ACF64; ACF65; ASP
Species Mus musculus
Ensembl Gene ENSMUSG00000052595
Encoded Proteins
IDBP-158363
APOBEC1 complementation factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148584:
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:31868761-31949406
Strand Forward strand
Band C1
Transcripts
ENSMUST00000075838 ENSMUSP00000075235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0016554 cytidine to uridine editing
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0030895 apolipoprotein B mRNA editing enzyme complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148584
View Gene Order
ENSBTAG00000021195
Not yet available
Pathways
NETPATH
REACTOME
REACT_256546
Formation of the Editosome pathway
REACT_254064
mRNA Editing: C to U Conversion pathway
REACT_233572
Gene Expression pathway
REACT_261262
mRNA Editing pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1390
Formation of the Editosome pathway
REACT_167
mRNA Editing: C to U Conversion pathway
REACT_1757
mRNA Editing pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.87538
RefSeq NM_001081074 XM_006527332
OMIM
CCDS CCDS37959
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca