Version 5.4
Bos taurus Gene: A1CF
Summary
InnateDB Gene IDBG-637119.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A1CF
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021195
Encoded Proteins
IDBP-689128
APOBEC1 complementation factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148584:
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:8523899-8580001
Strand Forward strand
Band
Transcripts
ENSBTAT00000033157 ENSBTAP00000033080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
Biological Process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000148584
View Gene Order
ENSMUSG00000052595
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1390
Formation of the Editosome pathway
REACT_167
mRNA Editing: C to U Conversion pathway
REACT_1757
mRNA Editing pathway
REACT_71
Gene Expression pathway
REACT_256546
Formation of the Editosome pathway
REACT_254064
mRNA Editing: C to U Conversion pathway
REACT_233572
Gene Expression pathway
REACT_261262
mRNA Editing pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1B7G9
UniProt Splice Variant
Entrez Gene 100336715
UniGene
RefSeq XM_002698365 XM_005225372 XM_005225373 XM_005225374
HUGO HGNC:24086
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02058697 DAAA02058698
GenPept
RNA Seq Atlas 100336715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca