Version 5.4
Mus musculus Gene: Asah2
Summary
InnateDB Gene IDBG-158400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asah2
Gene Name N-acylsphingosine amidohydrolase 2
Synonyms AI585898
Species Mus musculus
Ensembl Gene ENSMUSG00000024887
Encoded Proteins
IDBP-158402
N-acylsphingosine amidohydrolase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188611:
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:31984654-32061469
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000096119 ENSMUSP00000093830
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017040 ceramidase activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006915 apoptotic process
GO:0008283 cell proliferation
GO:0010033 response to organic substance
Cellular Component
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188611
View Gene Order
ENSBTAG00000003529
Not yet available
Pathways
NETPATH
REACTOME
REACT_199008
Glycosphingolipid metabolism pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
KEGG
mmu00600
Sphingolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q9JHE3
TrEMBL B7ZN55 B9EHG7
UniProt Splice Variant
Entrez Gene 54447
UniGene Mm.104900 Mm.404449
RefSeq NM_018830 XM_006527199 XM_006527200
OMIM
CCDS CCDS29749
HPRD
IMGT
MGI ID MGI:1859310
MGI Symbol Asah2
EMBL AB037111 AB037181 AK047692 AK080951 AK136189 AK166100 BC022604 BC137898 BC145016 CH466534
GenPept AAH22604 AAI37899 AAI45017 BAA94545 BAA94546 BAC33126 BAC38089 BAE22865 BAE38571 EDL41717
RNA Seq Atlas 54447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca