Version 5.4
Homo sapiens Gene: NTAN1
Summary
InnateDB Gene IDBG-15842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTAN1
Gene Name N-terminal asparagine amidase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157045
Encoded Proteins
IDBP-15844
N-terminal asparagine amidase
IDBP-748763
IDBP-751719
IDBP-753465
IDBP-753901
IDBP-753672
IDBP-807446
N-terminal asparagine amidase
IDBP-807447
N-terminal asparagine amidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:15037853-15056079
Strand Reverse strand
Band p13.11
Transcripts
ENST00000287706 ENSP00000287706
ENST00000568320 ENSP00000455396
ENST00000570292
ENST00000567420
ENST00000563940 ENSP00000456142
ENST00000567030
ENST00000566542
ENST00000566419 ENSP00000454883
ENST00000568738 ENSP00000454595
ENST00000565187 ENSP00000457467
ENST00000624579 ENSP00000485340
ENST00000622833 ENSP00000483643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008418 protein-N-terminal asparagine amidohydrolase activity
Biological Process
GO:0007613 memory
GO:0008152 metabolic process
GO:0008344 adult locomotory behavior
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022681
View Gene Order
ENSBTAG00000004803
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592045
RefSeq NM_001270766 NM_001270767 NM_173474
HUGO
OMIM
CCDS CCDS10558 CCDS73832
HPRD 17649
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca