Version 5.4
Mus musculus Gene: Mll1
Summary
InnateDB Gene IDBG-158453.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mll1
Gene Name myeloid/lymphoid or mixed-lineage leukemia 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000002028
Encoded Proteins
IDBP-158457
myeloid/lymphoid or mixed-lineage leukemia 1
IDBP-251220
myeloid/lymphoid or mixed-lineage leukemia 1
IDBP-788634
lysine (K)-specific methyltransferase 2A
IDBP-788638
lysine (K)-specific methyltransferase 2A
IDBP-538386
myeloid/lymphoid or mixed-lineage leukemia 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118058:
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:44803355-44881296
Strand Reverse strand
Band A5.2
Transcripts
ENSMUST00000002095 ENSMUSP00000002095
ENSMUST00000114689 ENSMUSP00000110337
ENSMUST00000138119 ENSMUSP00000138138
ENSMUST00000152241 ENSMUSP00000138767
ENSMUST00000128768 ENSMUSP00000122541
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 90 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 6 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 90 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044212 transcription regulatory region DNA binding
GO:0045322 unmethylated CpG binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006306 DNA methylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0008285 negative regulation of cell proliferation
GO:0009952 anterior/posterior pattern specification
GO:0032411 positive regulation of transporter activity
GO:0035162 embryonic hemopoiesis
GO:0043984 histone H4-K16 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051568 histone H3-K4 methylation
GO:0051569 regulation of histone H3-K4 methylation
GO:0080182 histone H3-K4 trimethylation
GO:2001040 positive regulation of cellular response to drug
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035097 histone methyltransferase complex
GO:0071339 MLL1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118058
View Gene Order
ENSBTAG00000018093
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2389 Mm.418071 Mm.418250
RefSeq NM_001081049 XM_006510128 XM_006510129 XM_006510130
OMIM
CCDS CCDS40603
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca