InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MLL

Summary

InnateDB Gene

IDBG-631302.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLL

Gene Name

Uncharacterized protein

Synonyms

MLL

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018093

Encoded Proteins

IDBP-682879

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118058:
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:29667707-29715637

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024084

ENSBTAP00000024084

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding
GO:0045322	unmethylated CpG binding
GO:0046872	metal ion binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006306	DNA methylation
GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0008285	negative regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0032259	methylation
GO:0032411	positive regulation of transporter activity
GO:0035162	embryonic hemopoiesis
GO:0043984	histone H4-K16 acetylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051568	histone H3-K4 methylation
GO:0051569	regulation of histone H3-K4 methylation
GO:0080182	histone H3-K4 trimethylation
GO:2001040	positive regulation of cellular response to drug

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0035097	histone methyltransferase complex
GO:0071339	MLL1 complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000118058

View Gene Order

ENSMUSG00000002028

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00310

Lysine degradation pathway

mmu00310

Lysine degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MHA1

UniProt Splice Variant

Entrez Gene

508330

UniGene

Bt.105982

RefSeq

XM_002693076 XM_585092

HUGO

HGNC:7132

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02040472

GenPept

RNA Seq Atlas

508330