Version 5.4
Mus musculus Gene: Srpk1
Summary
InnateDB Gene IDBG-158718.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srpk1
Gene Name serine/arginine-rich protein specific kinase 1
Synonyms AU017960
Species Mus musculus
Ensembl Gene ENSMUSG00000004865
Encoded Proteins
IDBP-158720
serine/arginine-rich protein specific kinase 1
IDBP-251071
serine/arginine-rich protein specific kinase 1
IDBP-539784
serine/arginine-rich protein specific kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096063:
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28587648-28622521
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000004987 ENSMUSP00000004987
ENSMUST00000114767 ENSMUSP00000110415
ENSMUST00000130643 ENSMUSP00000116259
ENSMUST00000136504
ENSMUST00000126683
ENSMUST00000145730
ENSMUST00000145023
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 191 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 191 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0007059 chromosome segregation
GO:0008380 RNA splicing
GO:0030154 cell differentiation
GO:0035556 intracellular signal transduction
GO:0045070 positive regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0050684 regulation of mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016363 nuclear matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000096063
View Gene Order
ENSBTAG00000016838
Not yet available
Cross-References
SwissProt O70551
TrEMBL Q3TTF9 Q3UB06 Q3URR1 Q3US65
UniProt Splice Variant
Entrez Gene 20815
UniGene Mm.15252 Mm.479188
RefSeq NM_016795
OMIM
CCDS CCDS37531
HPRD
IMGT
MGI ID MGI:106908
MGI Symbol Srpk1
EMBL AB012290 AJ224115 AK140761 AK141271 AK151152 AK161388 BC005707 BC050761
GenPept AAH05707 AAH50761 BAA25299 BAE24470 BAE24627 BAE30158 BAE36366 CAA11833
RNA Seq Atlas 20815

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca