Version 5.4
Homo sapiens Gene: USP3
Summary
InnateDB Gene IDBG-15895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP3
Gene Name ubiquitin specific peptidase 3
Synonyms SIH003; UBP
Species Homo sapiens
Ensembl Gene ENSG00000140455
Encoded Proteins
IDBP-15897
ubiquitin specific peptidase 3
IDBP-15899
ubiquitin specific peptidase 3
IDBP-599825
ubiquitin specific peptidase 3
IDBP-596994
ubiquitin specific peptidase 3
IDBP-586495
ubiquitin specific peptidase 3
IDBP-589826
ubiquitin specific peptidase 3
IDBP-583650
ubiquitin specific peptidase 3
IDBP-599689
ubiquitin specific peptidase 3
IDBP-597265
ubiquitin specific peptidase 3
IDBP-591315
ubiquitin specific peptidase 3
IDBP-602460
ubiquitin specific peptidase 3
IDBP-584896
ubiquitin specific peptidase 3
IDBP-600256
ubiquitin specific peptidase 3
IDBP-591644
ubiquitin specific peptidase 3
IDBP-597870
ubiquitin specific peptidase 3
IDBP-594838
ubiquitin specific peptidase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:63504511-63594640
Strand Forward strand
Band q22.31
Transcripts
ENST00000380324 ENSP00000369681
ENST00000268049 ENSP00000268049
ENST00000561442 ENSP00000453688
ENST00000560070 ENSP00000453194
ENST00000557884 ENSP00000454043
ENST00000558157 ENSP00000452929
ENST00000561326
ENST00000559873 ENSP00000453767
ENST00000559192 ENSP00000453228
ENST00000559771 ENSP00000453093
ENST00000559276 ENSP00000454197
ENST00000558285 ENSP00000453619
ENST00000559257 ENSP00000452947
ENST00000538686 ENSP00000445793
ENST00000559711 ENSP00000453138
ENST00000558925
ENST00000558218
ENST00000561381
ENST00000559718
ENST00000560202 ENSP00000453489
ENST00000540797 ENSP00000445828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0036459 ubiquitinyl hydrolase activity
GO:0042393 histone binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016578 histone deubiquitination
GO:0031647 regulation of protein stability
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032376
View Gene Order
ENSBTAG00000008805
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.458499 Hs.603083
RefSeq NM_001256702 NM_006537 XM_005254816
HUGO
OMIM
CCDS CCDS32265 CCDS58370
HPRD 05290
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca