InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP3

Summary

InnateDB Protein

IDBP-15897.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP3

Protein Name

ubiquitin specific peptidase 3

Synonyms

SIH003; UBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000369681

InnateDB Gene

IDBG-15895 (USP3)

Protein Structure

UniProt Annotation

Function

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin. {ECO:0000269PubMed:17980597}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17980597}. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.

Disease Associations

Tissue Specificity

Expressed in all tissues examined, with strongest expression in pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0008270	zinc ion binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042393	histone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016578	histone deubiquitination
GO:0031647	regulation of protein stability

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR001607 Zinc finger, UBP-type
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF02148

PRINTS

PIRSF

SMART

SM00290

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y6I4