InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Asb3

Summary

InnateDB Gene

IDBG-159076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asb3

Gene Name

ankyrin repeat and SOCS box-containing 3

Synonyms

2400011J03Rik; Asb-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020305

Encoded Proteins

IDBP-159078

ankyrin repeat and SOCS box-containing 3

IDBP-400946

ankyrin repeat and SOCS box-containing 3

IDBP-539703

ankyrin repeat and SOCS box-containing 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115239:
This locus represents naturally occurring read-through transcription between the neighboring GPR75 (G protein-coupled receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on chromosome 2. The transcript includes exons from both GPR75 and ASB3 and translation initiates in the 5' non-coding exon of GPR75. The resulting protein has a novel N-terminus but is otherwise identical to that encoded by ASB3.[provided by RefSeq, Feb 2011] The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:30954395-31102704

Strand

Forward strand

Band

Transcripts

ENSMUST00000020551	ENSMUSP00000020551
ENSMUST00000117883	ENSMUSP00000113072
ENSMUST00000137306	ENSMUSP00000114692
ENSMUST00000148163
ENSMUST00000148808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150	biological_process
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005575

cellular_component

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115239

View Gene Order

ENSBTAG00000019458

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.400619

RefSeq

NM_023906 XM_006514771 XM_006514772

OMIM

CCDS

CCDS24511

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas