Version 5.4
Mus musculus Protein: Asb3
Summary
InnateDB Protein IDBP-159078.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asb3
Protein Name ankyrin repeat and SOCS box-containing 3
Synonyms 2400011J03Rik; Asb-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000020551
InnateDB Gene IDBG-159076 (Asb3)
Protein Structure
UniProt Annotation
Function Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed; highest expression in testis and spleen. {ECO:0000269PubMed:11111040}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:1929749
InterPro IPR001496 SOCS protein, C-terminal
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF07525
PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00253
SM00969
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WV72
PhosphoSite PhosphoSite-Q9WV72
TrEMBL
UniProt Splice Variant
Entrez Gene 65257
UniGene Mm.400619
RefSeq NP_076395
MGI ID
MGI Symbol Asb3
OMIM
CCDS CCDS24511
HPRD
IMGT
EMBL AF155354 AK143580 AL646095 AL662891 AL732621
GenPept AAD38810 BAE25448 CAI24293 CAI24539 CAI25026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca