Version 5.4
Mus musculus Gene: Il1rapl1
Summary
InnateDB Gene IDBG-159079.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il1rapl1
Gene Name interleukin 1 receptor accessory protein-like 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000052372
Encoded Proteins
IDBP-159081
interleukin 1 receptor accessory protein-like 1
IDBP-252763
interleukin 1 receptor accessory protein-like 1
IDBP-252767
interleukin 1 receptor accessory protein-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25654981
[Homo sapiens] IL37 acts as an extracellular cytokine to inhibit innate inflammation by binding to IL18R1 and then using IL1RAPL1 for its anti-inflammatory properties.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169306:
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:86740870-88115645
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000078875 ENSMUSP00000077915
ENSMUST00000113966 ENSMUSP00000109599
ENSMUST00000113964 ENSMUSP00000109597
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0045920 negative regulation of exocytosis
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000169306
View Gene Order
Cross-References
SwissProt
TrEMBL B1ASU0 Q0VDP7
UniProt Splice Variant
Entrez Gene 331461
UniGene Mm.121680 Mm.400887 Mm.409099 Mm.426143
RefSeq NM_001160403 XM_006528100
OMIM
CCDS CCDS53128
HPRD
IMGT
MGI ID MGI:2687319
MGI Symbol Il1rapl1
EMBL AL627409 AL672059 AL731705 AL844869 AL844900 AL954362 BC119580 BX005231 BX088567 BX649618 BX890584 CR538724
GenPept AAI19581
RNA Seq Atlas 331461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca