Homo sapiens Gene: IL1RAPL1

Summary
InnateDB Gene IDBG-53480.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol IL1RAPL1
Gene Name interleukin 1 receptor accessory protein-like 1
Synonyms IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2
Species Homo sapiens
Ensembl Gene ENSG00000169306
Encoded Proteins
IDBP-53482 interleukin 1 receptor accessory protein-like 1
IDBP-53484 interleukin 1 receptor accessory protein-like 1
Entrez Gene
Summary The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X: 28605516-29974840
Strand Forward strand
Band p21.2
Transcripts
ENST00000378993  ENSP00000368278
ENST00000302196  ENSP00000305200
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein‑Protein  4
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005102 receptor binding
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0007157 heterophilic cell-cell adhesion
GO:0007165 signal transduction
GO:0010975 regulation of neuron projection development
GO:0030182 neuron differentiation
GO:0045087 innate immune response
GO:0045920 negative regulation of exocytosis
GO:0050775 positive regulation of dendrite morphogenesis
GO:0097105 presynaptic membrane assembly
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral to membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000052372 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9NZN1 
TrEMBL Q7Z2H0
UniProt Splice Variant
Entrez Gene 11141 
UniGene Hs.658912
RefSeq NM_014271 
HUGO 5996 
OMIM 300206
CCDS CCDS14218 
HPRD 02193
IMGT
EMBL AB101891 AB101892 AB101893 AB101894 AB101895 AB101896 AB101897 AB101898 AB101899 AB101901 AB101902 AB101903 AB101904 AB101905 AB101906 AB101907 AB101908 AB101909 AB101910 AB102650 AC005748 AC121343 AC129852 AF181284 AF284435 AJ243874 AL031466 AL031575 BC126345 BC126347 CH471074
GenPept AAF59411  AAG21369  AAI26346  AAI26348  BAC80450  BAC80451  BAC80452  BAC80453  BAC80454  BAC80455  BAC80456  BAC80457  BAC80458  BAC80460  BAC80461  BAC80462  BAC80463  BAC80464  BAC80465  BAC80466  BAC80467  BAC80468  BAC80469  BAC81119  CAB56046  CAI42035  CAI42992  EAW99046 
ImmGen IL1RAPL1 (murine) 
RNA Seq Atlas 11141