Homo sapiens Gene: IL1RAPL1
Summary
InnateDB Gene IDBG-53480.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1RAPL1
Gene Name interleukin 1 receptor accessory protein-like 1
Synonyms IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2;
Species Homo sapiens
Ensembl Gene ENSG00000169306
Encoded Proteins
interleukin 1 receptor accessory protein-like 1
interleukin 1 receptor accessory protein-like 1
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:28587399-29956723
Strand Forward strand
Band p21.3
Transcripts
ENST00000378993 ENSP00000368278
ENST00000302196 ENSP00000305200
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0007157 heterophilic cell-cell adhesion
GO:0007165 signal transduction
GO:0010975 regulation of neuron projection development
GO:0030182 neuron differentiation
GO:0045920 negative regulation of exocytosis
GO:0050775 positive regulation of dendrite morphogenesis
GO:0070588 calcium ion transmembrane transport
GO:0097105 presynaptic membrane assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt Q9NZN1
TrEMBL Q7Z2H0 X5DNQ7
UniProt Splice Variant
Entrez Gene 11141
UniGene Hs.658912
RefSeq NM_014271 XM_005274441
HUGO HGNC:5996
OMIM 300206
CCDS CCDS14218
HPRD 02193
IMGT
EMBL AB101891 AB101892 AB101893 AB101894 AB101895 AB101896 AB101897 AB101898 AB101899 AB101901 AB101902 AB101903 AB101904 AB101905 AB101906 AB101907 AB101908 AB101909 AB101910 AB102650 AC005748 AC121343 AC129852 AF181284 AF284435 AJ243874 AL031466 AL031575 BC126345 BC126347 CH471074 KJ534871
GenPept AAF59411 AAG21369 AAI26346 AAI26348 AHW56511 BAC80450 BAC80451 BAC80452 BAC80453 BAC80454 BAC80455 BAC80456 BAC80457 BAC80458 BAC80460 BAC80461 BAC80462 BAC80463 BAC80464 BAC80465 BAC80466 BAC80467 BAC80468 BAC80469 BAC81119 CAB56046 CAI42035 CAI42992 EAW99046
ImmGen IL1RAPL1 (murine)
RNA Seq Atlas 11141