InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd3e

Summary

InnateDB Gene

IDBG-159085.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Cd3e

Gene Name

CD3 antigen, epsilon polypeptide

Synonyms

AI504783; CD3; CD3epsilon; T3e;

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032093

Encoded Proteins

IDBP-159087

CD3 antigen, epsilon polypeptide

Protein Structure

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198851:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:44998743-45009590

Strand

Reverse strand

Band

A5.2

Transcripts

ENSMUST00000102832

ENSMUSP00000099896

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002669	positive regulation of T cell anergy
GO:0007166	cell surface receptor signaling pathway
GO:0007584	response to nutrient
GO:0032729	positive regulation of interferon-gamma production
GO:0032753	positive regulation of interleukin-4 production
GO:0033077	T cell differentiation in thymus
GO:0042102	positive regulation of T cell proliferation
GO:0045060	negative thymic T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0046649	lymphocyte activation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral to membrane
GO:0042101	T cell receptor complex
GO:0042105	alpha-beta T cell receptor complex