Version 5.4
Mus musculus Gene: Cd3e
Summary
InnateDB Gene IDBG-159085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd3e
Gene Name CD3 antigen, epsilon polypeptide
Synonyms AI504783; CD3; CD3epsilon; T3e;
Species Mus musculus
Ensembl Gene ENSMUSG00000032093
Encoded Proteins
IDBP-159087
CD3 antigen, epsilon polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198851:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:44998743-45009590
Strand Reverse strand
Band A5.2
Transcripts
ENSMUST00000102832 ENSMUSP00000099896
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002669 positive regulation of T cell anergy
GO:0007166 cell surface receptor signaling pathway
GO:0007584 response to nutrient
GO:0031295 T cell costimulation
GO:0032729 positive regulation of interferon-gamma production
GO:0032753 positive regulation of interleukin-4 production
GO:0033077 T cell differentiation in thymus
GO:0042102 positive regulation of T cell proliferation
GO:0045060 negative thymic T cell selection
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046649 lymphocyte activation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000198851
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000015710
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_263643
PD-1 signaling pathway
REACT_216080
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_225145
Downstream TCR signaling pathway
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_215414
Translocation of ZAP-70 to Immunological synapse pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_229531
Adaptive Immune System pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_222648
TCR signaling pathway
KEGG
mmu04640
Hematopoietic cell lineage pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
mmu05340
Primary immunodeficiency pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_19324
PD-1 signaling pathway
REACT_12526
TCR signaling pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12555
Downstream TCR signaling pathway
REACT_12582
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12596
Translocation of ZAP-70 to Immunological synapse pathway
REACT_213223
PD-1 signaling pathway
REACT_212961
Phosphorylation of CD3 and TCR zeta chains pathway
REACT_213843
Costimulation by the CD28 family pathway
REACT_205423
Downstream TCR signaling pathway
REACT_213138
Immune System pathway
REACT_214469
Adaptive Immune System pathway
REACT_218413
Generation of second messenger molecules pathway
REACT_202824
Translocation of ZAP-70 to Immunological synapse pathway
REACT_213465
TCR signaling pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05340
Primary immunodeficiency pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID BIOCARTA
100193
The co-stimulatory signal during t-cell activation [Biocarta view]
100109
Role of mef2d in t-cell apoptosis [Biocarta view]
100023
Lck and fyn tyrosine kinases in initiation of tcr activation [Biocarta view]
100022
T cell receptor signaling pathway [Biocarta view]
100196
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cxcr4_pathway
CXCR4-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
il12_stat4pathway
IL12 signaling mediated by STAT4
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt P22646
TrEMBL A6H6M1
UniProt Splice Variant
Entrez Gene 12501
UniGene
RefSeq NM_007648 XM_006509966
OMIM
CCDS CCDS23125
HPRD
IMGT
MGI ID MGI:88332
MGI Symbol Cd3e
EMBL BC145926 BC145954 GU456631 J02990 M23370 M23371 M23372 M23373 M23374 M23375 M23376
GenPept AAA40296 AAA72720 AAI45927 AAI45955 ADD13994
RNA Seq Atlas 12501

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca