Mus musculus Gene: Cd3e

Summary
InnateDB Gene IDBG-159085.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Cd3e
Gene Name CD3 antigen, epsilon polypeptide
Synonyms AI504783; CD3; CD3epsilon; T3e
Species Mus musculus
Ensembl Gene ENSMUSG00000032093
Encoded Proteins
IDBP-159087 CD3 antigen, epsilon polypeptide
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198851:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9: 44998743-45009590
Strand Reverse strand
Band A5.2
Transcripts
ENSMUST00000102832  ENSMUSP00000099896
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein‑Protein  10
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 27 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002669 positive regulation of T cell anergy
GO:0007166 cell surface receptor signaling pathway
GO:0007584 response to nutrient
GO:0032729 positive regulation of interferon-gamma production
GO:0032753 positive regulation of interleukin-4 production
GO:0033077 T cell differentiation in thymus
GO:0042102 positive regulation of T cell proliferation
GO:0045060 negative thymic T cell selection
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046649 lymphocyte activation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0042101 T cell receptor complex
GO:0042105 alpha-beta T cell receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000198851 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000015710 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_139195 Downstream TCR signaling
REACT_101527 Generation of second messenger molecules
REACT_107426 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_82851 PD-1 signaling
REACT_106516 Phosphorylation of CD3 and TCR zeta chains
REACT_148978 Translocation of ZAP-70 to Immunological synapse
KEGG
mmu05142  Chagas disease (American trypanosomiasis)
mmu04640  Hematopoietic cell lineage
mmu05340  Primary immunodeficiency
mmu04660  T cell receptor signaling pathway
INOH
INOH website CD4 T cell receptor signaling
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_56 Prolactin pathway
NetPath_11 TCR pathway
REACTOME
REACT_12555 Downstream TCR signaling
REACT_12623 Generation of second messenger molecules
REACT_11152 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REACT_19324 PD-1 signaling
REACT_12582 Phosphorylation of CD3 and TCR zeta chains
REACT_12596 Translocation of ZAP-70 to Immunological synapse
KEGG
hsa05142  Chagas disease (American trypanosomiasis)
hsa04640  Hematopoietic cell lineage
hsa05340  Primary immunodeficiency
hsa04660  T cell receptor signaling pathway
INOH
INOH website CD4 T cell receptor signaling
PID BIOCARTA
100196 Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
100023 Lck and fyn tyrosine kinases in initiation of tcr activation [Biocarta view]
100109 Role of mef2d in t-cell apoptosis [Biocarta view]
100022 T cell receptor signaling pathway [Biocarta view]
100193 The co-stimulatory signal during t-cell activation [Biocarta view]
PID NCI
cxcr4_pathway CXCR4-mediated signaling events
cd8tcrdownstreampathway Downstream signaling in naïve CD8+ T cells
il12_stat4pathway IL12 signaling mediated by STAT4
il12_2pathway IL12-mediated signaling events
il23pathway IL23-mediated signaling events
tcr_pathway TCR signaling in naïve CD4+ T cells
cd8tcrpathway TCR signaling in naïve CD8+ T cells
Cross-References
SwissProt P22646 
TrEMBL A6H6M1
UniProt Splice Variant
Entrez Gene 12501 
UniGene
RefSeq NM_007648 
OMIM
CCDS CCDS23125 
HPRD
IMGT
MGI ID MGI:88332 
MGI Symbol Cd3e
EMBL BC145926 BC145954 GU456631 J02990 M23370 M23371 M23372 M23373 M23374 M23375 M23376
GenPept AAA40296  AAA72720  AAI45927  AAI45955  ADD13994 
ImmGen Cd3e (murine) 
RNA Seq Atlas 12501