InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd3e

Summary

InnateDB Protein

IDBP-159087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd3e

Protein Name

CD3 antigen, epsilon polypeptide

Synonyms

AI504783; CD3; CD3epsilon; T3e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099896

InnateDB Gene

IDBG-159085 (Cd3e)

Protein Structure

UniProt Annotation

Function

The CD3 complex mediates signal transduction.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002669	positive regulation of T cell anergy
GO:0007166	cell surface receptor signaling pathway
GO:0007584	response to nutrient
GO:0031295	T cell costimulation
GO:0032729	positive regulation of interferon-gamma production
GO:0032753	positive regulation of interleukin-4 production
GO:0033077	T cell differentiation in thymus
GO:0042102	positive regulation of T cell proliferation
GO:0045060	negative thymic T cell selection
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045879	negative regulation of smoothened signaling pathway
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0046649	lymphocyte activation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042101	T cell receptor complex
GO:0042105	alpha-beta T cell receptor complex

Protein Structure and Domains

PDB ID

MGI:88332

InterPro

IPR003110 Phosphorylated immunoreceptor signalling ITAM
IPR003598 Immunoglobulin subtype 2
IPR007110 Immunoglobulin-like domain
IPR013151 Immunoglobulin

PFAM

PF02189
PF00047

PRINTS

PIRSF

SMART

SM00077
SM00408

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P22646