Version 5.4
Mus musculus Gene: Uck1
Summary
InnateDB Gene IDBG-159207.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uck1
Gene Name uridine-cytidine kinase 1
Synonyms Umpk; URK1
Species Mus musculus
Ensembl Gene ENSMUSG00000002550
Encoded Proteins
IDBP-159209
uridine-cytidine kinase 1
IDBP-541101
uridine-cytidine kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130717:
This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:32255002-32260159
Strand Reverse strand
Band B
Transcripts
ENSMUST00000002625 ENSMUSP00000002625
ENSMUST00000133804
ENSMUST00000138133 ENSMUSP00000125350
ENSMUST00000142797
ENSMUST00000134351
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004140 dephospho-CoA kinase activity
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0008152 metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
GO:0044206 UMP salvage
GO:0044211 CTP salvage
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130717
View Gene Order
ENSBTAG00000010810
Not yet available
Pathways
NETPATH
REACTOME
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_259385
Pyrimidine salvage reactions pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu00983
Drug metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_655
Pyrimidine salvage reactions pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
REACT_224989
Pyrimidine metabolism pathway
REACT_210940
Metabolism of nucleotides pathway
REACT_219139
Metabolism pathway
REACT_210299
Pyrimidine salvage reactions pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 22245
UniGene Mm.425076
RefSeq NM_011675
OMIM
CCDS CCDS15909
HPRD
IMGT
MGI ID MGI:98904
MGI Symbol Uck1
EMBL
GenPept
RNA Seq Atlas 22245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca