Version 5.4
Homo sapiens Gene: UCK1
Summary
InnateDB Gene IDBG-90047.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCK1
Gene Name uridine-cytidine kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130717
Encoded Proteins
IDBP-90049
uridine-cytidine kinase 1
IDBP-90053
uridine-cytidine kinase 1
IDBP-90055
uridine-cytidine kinase 1
IDBP-90057
uridine-cytidine kinase 1
IDBP-592563
uridine-cytidine kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:131523801-131531268
Strand Reverse strand
Band q34.13
Transcripts
ENST00000372215 ENSP00000361289
ENST00000372211 ENSP00000361285
ENST00000372210 ENSP00000361284
ENST00000372208 ENSP00000361282
ENST00000491309 ENSP00000432363
ENST00000484876
ENST00000494584
ENST00000459858
ENST00000482398
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004140 dephospho-CoA kinase activity
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019206 nucleoside kinase activity
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0008152 metabolic process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
GO:0043097 pyrimidine nucleoside salvage
GO:0044206 UMP salvage
GO:0044211 CTP salvage
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002550
View Gene Order
ENSBTAG00000010810
Not yet available
Pathways
NETPATH
REACTOME
REACT_655
Pyrimidine salvage reactions pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q9HA47
TrEMBL
UniProt Splice Variant
Entrez Gene 83549
UniGene Hs.685093 Hs.9597
RefSeq NM_031432 NM_001135954 NM_001261450 NM_001261451 XM_005272224
HUGO HGNC:14859
OMIM 609328
CCDS CCDS6944 CCDS48046 CCDS59151 CCDS59152
HPRD 18256
IMGT
EMBL AF125106 AF237290 AF254133 AK022317 AK295471 AL358781 BC015547 BC091495 CH471090 CR457281
GenPept AAH15547 AAH91495 AAK28324 AAK49122 AAL75943 BAB14010 BAG58400 CAG33562 CAI40228 CAI40229 CAI40231 EAW87983
RNA Seq Atlas 83549

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca