InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP12A

Summary

InnateDB Gene

IDBG-15940.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP12A

Gene Name

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Synonyms

ATP1AL1

Species

Homo sapiens

Ensembl Gene

ENSG00000075673

Encoded Proteins

IDBP-15942

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

IDBP-15944

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:24680411-24712493

Strand

Forward strand

Band

q12.12

Transcripts

ENST00000218548	ENSP00000218548
ENST00000381946	ENSP00000371372

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008900	hydrogen:potassium-exchanging ATPase activity
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006885	regulation of pH
GO:0015672	monovalent inorganic cation transport
GO:0034220	ion transmembrane transport
GO:0055075	potassium ion homeostasis
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005889	hydrogen:potassium-exchanging ATPase complex
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022229

View Gene Order

ENSBTAG00000014486

Not yet available

Pathways

NETPATH

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

INOH

PID NCI

Cross-References

SwissProt

P54707

TrEMBL

UniProt Splice Variant

Entrez Gene

479

UniGene

Hs.147111

RefSeq

NM_001185085 NM_001676

HUGO

HGNC:13816

OMIM

182360

CCDS

CCDS31948 CCDS53858

HPRD

IMGT

EMBL

AK292968 AL157364 BC031609 CH471075 L42558 L42559 L42560 L42561 L42562 L42563 L42565 L42566 L42567 L42568 L42569 M16797 M27574 U02076 X69823 X69824

GenPept

AAA35576 AAA51802 AAB37755 AAC37589 AAH31609 BAF85657 CAA49477 CAA49478 CAH72440 EAX08345 EAX08346

RNA Seq Atlas

479