InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp12a

Summary

InnateDB Gene

IDBG-167042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp12a

Gene Name

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022229

Encoded Proteins

IDBP-167044

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075673:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:56365068-56388551

Strand

Forward strand

Band

Transcripts

ENSMUST00000007340

ENSMUSP00000007340

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008900	hydrogen:potassium-exchanging ATPase activity
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006885	regulation of pH
GO:0015672	monovalent inorganic cation transport
GO:0055075	potassium ion homeostasis
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000075673

View Gene Order

ENSBTAG00000014486

Not yet available

Pathways

NETPATH

REACTOME

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_250224

Ion transport by P-type ATPases pathway

KEGG

mmu00190

Oxidative phosphorylation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

INOH

PID NCI

Cross-References

SwissProt

Q9Z1W8

TrEMBL

UniProt Splice Variant

Entrez Gene

192113

UniGene

Mm.273271

RefSeq

NM_138652

OMIM

CCDS

CCDS27148

HPRD

IMGT

MGI ID

MGI:1926943

MGI Symbol

Atp12a

EMBL

AF100169 AF350499 BC109011

GenPept

AAD03421 AAI09012 AAL68709

RNA Seq Atlas

192113