Version 5.4
Mus musculus Gene: Pias2
Summary
InnateDB Gene IDBG-159490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pias2
Gene Name protein inhibitor of activated STAT 2
Synonyms 6330408K17Rik; AI462206; ARIP3; AU018068; Dib; Miz1; PIASxalpha; PIASxb; PIASxbeta; SIZ2
Species Mus musculus
Ensembl Gene ENSMUSG00000025423
Encoded Proteins
IDBP-251049
protein inhibitor of activated STAT 2
IDBP-251051
protein inhibitor of activated STAT 2
IDBP-623902
protein inhibitor of activated STAT 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 12764129
[Homo sapiens] Functions as an E3 ligase to promote STAT1 SUMO modification
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078043:
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:77065208-77155708
Strand Forward strand
Band E3
Transcripts
ENSMUST00000114777 ENSMUSP00000110425
ENSMUST00000114776 ENSMUSP00000110424
ENSMUST00000168882 ENSMUSP00000131485
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019789 SUMO ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0050681 androgen receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016925 protein sumoylation
GO:0045667 regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060766 negative regulation of androgen receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0016604 nuclear body
GO:0016605 PML body
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078043
View Gene Order
ENSBTAG00000007833
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu05222
Small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05222
Small cell lung cancer pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
il12_stat4pathway
IL12 signaling mediated by STAT4
ranbp2pathway
Sumoylation by RanBP2 regulates transcriptional repression
Cross-References
SwissProt Q8C5D8
TrEMBL F8WHS8 G3UWE3
UniProt Splice Variant
Entrez Gene 17344
UniGene Mm.470769 Mm.6370
RefSeq NM_001164167 NM_001164168 NM_001164169 NM_001164170 NM_008602 XM_006526423 XM_006526425
OMIM
CCDS CCDS37866 CCDS50323 CCDS50324
HPRD
IMGT
MGI ID MGI:1096566
MGI Symbol Pias2
EMBL AC132608 AC157991 AF039567 AF201391 AK014871 AK029716 AK078813 AK086653 BC005596 BC034711 CH466528
GenPept AAB96678 AAF12825 AAH05596 AAH34711 BAB29594 BAC26579 BAC37407 BAC39710 EDL09470
RNA Seq Atlas 17344

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca