Version 5.4
Mus musculus Gene: Acta2
Summary
InnateDB Gene IDBG-159493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acta2
Gene Name actin, alpha 2, smooth muscle, aorta
Synonyms 0610041G09Rik; a-SMA; Actvs; alphaSMA; SMalphaA
Species Mus musculus
Ensembl Gene ENSMUSG00000035783
Encoded Proteins
IDBP-159495
actin, alpha 2, smooth muscle, aorta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107796:
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:34241090-34255336
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000039631 ENSMUSP00000048218
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0008217 regulation of blood pressure
GO:0009615 response to virus
GO:0014829 vascular smooth muscle contraction
GO:0072144 glomerular mesangial cell development
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0030485 smooth muscle contractile fiber
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000107796
View Gene Order
Pathways
NETPATH
REACTOME
REACT_235059
Smooth Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_007392
OMIM
CCDS CCDS29757
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca