InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACTA2

Summary

InnateDB Gene

IDBG-81614.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTA2

Gene Name

actin, alpha 2, smooth muscle, aorta

Synonyms

AAT6; ACTSA; MYMY5

Species

Homo sapiens

Ensembl Gene

ENSG00000107796

Encoded Proteins

IDBP-81616

actin, alpha 2, smooth muscle, aorta

IDBP-382008

actin, alpha 2, smooth muscle, aorta

IDBP-382010

actin, alpha 2, smooth muscle, aorta

IDBP-382011

actin, alpha 2, smooth muscle, aorta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:88935074-88991390

Strand

Reverse strand

Band

q23.31

Transcripts

ENST00000224784	ENSP00000224784
ENST00000458208	ENSP00000402373
ENST00000415557	ENSP00000396730
ENST00000458159	ENSP00000398239
ENST00000480297
ENST00000488967
ENST00000482085

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	67 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019901	protein kinase binding

Biological Process

GO:0006936	muscle contraction
GO:0008217	regulation of blood pressure
GO:0009615	response to virus
GO:0014829	vascular smooth muscle contraction
GO:0072144	glomerular mesangial cell development

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0015629	actin cytoskeleton
GO:0030485	smooth muscle contractile fiber
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000035783

View Gene Order

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_20558

Smooth Muscle Contraction pathway

REACT_17044

Muscle contraction pathway

KEGG

hsa04270

Vascular smooth muscle contraction pathway

INOH

PID NCI

pdgfrbpathway

PDGFR-beta signaling pathway

Cross-References

SwissProt

P62736

TrEMBL

B3KPP5 B4DUI8 D2JYH4 F6QUT6 F6UVQ4 Q562S2

UniProt Splice Variant

Entrez Gene

UniGene

Hs.500483 Hs.635256

RefSeq

NM_001613 NM_001141945

HUGO

HGNC:130

OMIM

102620

CCDS

CCDS7392

HPRD

00031

IMGT

EMBL

AK056592 AK300664 AK313294 AL157394 AY692464 AY970439 AY970440 BC017554 BC093052 CH471066 CR536518 GU143396 J05192 K01741 K01742 K01743 M33216 X13839

GenPept

AAA51577 AAA60560 AAH17554 AAH93052 AAW29811 AAX82248 AAX82249 ACZ58370 BAG36101 BAG51757 BAG62350 CAA32064 CAG38756 CAI13864 EAW50153 EAW50154 EAW50155

RNA Seq Atlas