Version 5.4
Mus musculus Gene: Ch25h
Summary
InnateDB Gene IDBG-159640.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ch25h
Gene Name cholesterol 25-hydroxylase
Synonyms AI462618; m25OH
Species Mus musculus
Ensembl Gene ENSMUSG00000050370
Encoded Proteins
IDBP-159642
cholesterol 25-hydroxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138135:
This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:34473786-34475135
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000050562 ENSMUSP00000049683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001567 cholesterol 25-hydroxylase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0016126 sterol biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138135
View Gene Order
ENSBTAG00000011115
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_207530
Synthesis of bile acids and bile salts pathway
REACT_229469
Bile acid and bile salt metabolism pathway
KEGG
mmu00120
Primary bile acid biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00120
Primary bile acid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9Z0F5
TrEMBL
UniProt Splice Variant
Entrez Gene 12642
UniGene Mm.30824 Mm.416275
RefSeq NM_009890
OMIM
CCDS CCDS29759
HPRD
IMGT
MGI ID MGI:1333869
MGI Symbol Ch25h
EMBL AF059211 AF059213 AK140360 AK152770 AK160657 BC039919
GenPept AAC97480 AAC97482 AAH39919 BAE24352 BAE31482 BAE35945
RNA Seq Atlas 12642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca