InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cer1

Summary

InnateDB Gene

IDBG-159643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cer1

Gene Name

cerberus 1 homolog (Xenopus laevis)

Synonyms

cer-1; Cerl; Cerl1; Cerr1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038192

Encoded Proteins

IDBP-159645

cerberus 1 homolog (Xenopus laevis)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147869:
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:82881751-82885148

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048430

ENSMUSP00000048607

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0016015	morphogen activity
GO:0036122	BMP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001657	ureteric bud development
GO:0003419	growth plate cartilage chondrocyte proliferation
GO:0007369	gastrulation
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0009948	anterior/posterior axis specification
GO:0009952	anterior/posterior pattern specification
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030282	bone mineralization
GO:0030514	negative regulation of BMP signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0035582	sequestering of BMP in extracellular matrix
GO:0042074	cell migration involved in gastrulation
GO:0048263	determination of dorsal identity
GO:0071773	cellular response to BMP stimulus
GO:2000381	negative regulation of mesoderm development