InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdk3

Summary

InnateDB Gene

IDBG-159868.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdk3

Gene Name

pyruvate dehydrogenase kinase, isoenzyme 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035232

Encoded Proteins

IDBP-159870

pyruvate dehydrogenase kinase, isoenzyme 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067992:
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:93764607-93832201

Strand

Reverse strand

Band

Transcripts

ENSMUST00000045748	ENSMUSP00000036604
ENSMUST00000154717
ENSMUST00000134502

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006006	glucose metabolic process
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906	regulation of glucose metabolic process
GO:0018105	peptidyl-serine phosphorylation
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0071333	cellular response to glucose stimulus
GO:0071398	cellular response to fatty acid
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway
GO:2000377	regulation of reactive oxygen species metabolic process