InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDK3

Summary

InnateDB Gene

IDBG-638382.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDK3

Gene Name

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017832

Encoded Proteins

IDBP-690443

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067992:
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:125848355-125930675

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023706

ENSBTAP00000023706

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906	regulation of glucose metabolic process
GO:0018105	peptidyl-serine phosphorylation
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0071398	cellular response to fatty acid
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway
GO:2000377	regulation of reactive oxygen species metabolic process