InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mef2d

Summary

InnateDB Gene

IDBG-159892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mef2d

Gene Name

myocyte enhancer factor 2D

Synonyms

C80750

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001419

Encoded Proteins

IDBP-159894

myocyte enhancer factor 2D

IDBP-266409

myocyte enhancer factor 2D

IDBP-266411

myocyte enhancer factor 2D

IDBP-401169

myocyte enhancer factor 2D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116604:
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:88142372-88172086

Strand

Forward strand

Band

Transcripts

ENSMUST00000001455	ENSMUSP00000001455
ENSMUST00000107559	ENSMUSP00000103184
ENSMUST00000107558	ENSMUSP00000103183
ENSMUST00000119251	ENSMUSP00000113638
ENSMUST00000140927
ENSMUST00000139153
ENSMUST00000152861

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0033613	activating transcription factor binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0001958	endochondral ossification
GO:0002062	chondrocyte differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007399	nervous system development
GO:0007512	adult heart development
GO:0035914	skeletal muscle cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter