InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nr1i2

Summary

InnateDB Gene

IDBG-159925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr1i2

Gene Name

nuclear receptor subfamily 1, group I, member 2

Synonyms

mPXR; PXR; PXR.1; PXR.2; PXR1; SXR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022809

Encoded Proteins

IDBP-159927

nuclear receptor subfamily 1, group I, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144852:
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:38248323-38294824

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023504

ENSMUSP00000023504

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006805	xenobiotic metabolic process
GO:0010628	positive regulation of gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0042738	exogenous drug catabolic process
GO:0042908	xenobiotic transport
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046618	drug export

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000144852

View Gene Order

ENSBTAG00000019557

Not yet available

Pathways

NETPATH

REACTOME

REACT_234105

Nuclear Receptor transcription pathway pathway

REACT_233572

Gene Expression pathway

REACT_206529

Generic Transcription Pathway pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.8509

RefSeq

NM_001098404 NM_010936 XM_006521846 XM_006521848

OMIM

CCDS

CCDS28164

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas