Version 5.4
Homo sapiens Gene: NR1I2
Summary
InnateDB Gene IDBG-51560.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR1I2
Gene Name nuclear receptor subfamily 1, group I, member 2
Synonyms BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
Species Homo sapiens
Ensembl Gene ENSG00000144852
Encoded Proteins
IDBP-51562
nuclear receptor subfamily 1, group I, member 2
IDBP-243048
nuclear receptor subfamily 1, group I, member 2
IDBP-484020
nuclear receptor subfamily 1, group I, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:119780484-119818485
Strand Forward strand
Band q13.33
Transcripts
ENST00000337940 ENSP00000336528
ENST00000393716 ENSP00000377319
ENST00000466380 ENSP00000420297
ENST00000474090
ENST00000493757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 51 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887 thyroid hormone receptor activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006805 xenobiotic metabolic process
GO:0007165 signal transduction
GO:0008202 steroid metabolic process
GO:0010467 gene expression
GO:0010628 positive regulation of gene expression
GO:0030522 intracellular receptor signaling pathway
GO:0042738 exogenous drug catabolic process
GO:0042908 xenobiotic transport
GO:0043401 steroid hormone mediated signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046618 drug export
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022809
View Gene Order
ENSBTAG00000019557
Not yet available
Cross-References
SwissProt
TrEMBL H0Y8E2
UniProt Splice Variant
Entrez Gene 8856
UniGene Hs.7303
RefSeq NM_033013 NM_003889 NM_022002
HUGO HGNC:7968
OMIM 603065
CCDS CCDS54627 CCDS2995 CCDS43136
HPRD 04346
IMGT
EMBL AC069444 CH471052
GenPept EAW79539
RNA Seq Atlas 8856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca