Version 5.4
Mus musculus Gene: Eif2s3x
Summary
InnateDB Gene IDBG-160094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2s3x
Gene Name eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
Synonyms AA409828; AA547477; AI314668; Eif-2gx
Species Mus musculus
Ensembl Gene ENSMUSG00000035150
Encoded Proteins
IDBP-160096
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
IDBP-252864
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130741:
The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:94188707-94212862
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000050328 ENSMUSP00000059395
ENSMUST00000113922 ENSMUSP00000109555
ENSMUST00000127963
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008135 translation factor activity, nucleic acid binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006413 translational initiation
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130741
View Gene Order
ENSBTAG00000014337
Not yet available
Pathways
NETPATH
REACTOME
REACT_255163
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_254308
Translation pathway
REACT_256488
Translation initiation complex formation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_233572
Gene Expression pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_236458
Ribosomal scanning and start codon recognition pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_229709
Recycling of eIF2:GDP pathway
REACT_249316
Formation of the ternary complex, and subsequently, the 43S complex pathway
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_1815
Recycling of eIF2:GDP pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_203882
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_246268
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_209048
Translation pathway
REACT_206472
Recycling of eIF2:GDP pathway
REACT_202903
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_213782
Metabolism of proteins pathway
REACT_220444
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_224343
Translation initiation complex formation pathway
REACT_222420
Ribosomal scanning and start codon recognition pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt Q9Z0N1
TrEMBL Q3TML6 Q6NY07 Q9CRE9
UniProt Splice Variant
Entrez Gene 26905
UniGene Mm.218851 Mm.473934
RefSeq NM_012010 XM_006528045 XM_006544849
OMIM
CCDS CCDS30277
HPRD
IMGT
MGI ID MGI:1349431
MGI Symbol Eif2s3x
EMBL AJ006587 AK010819 AK165866 BC063755 BC066793 BC139234 BC139235 CH466637
GenPept AAH63755 AAH66793 AAI39235 AAI39236 BAB27202 BAE38425 CAA07099 EDL29750
RNA Seq Atlas 102642679 26905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca