InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2s3x

Summary

InnateDB Protein

IDBP-160096.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2s3x

Protein Name

eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked

Synonyms

AA409828; AA547477; AI314668; Eif-2gx;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059395

InnateDB Gene

IDBG-160094 (Eif2s3x)

Protein Structure

UniProt Annotation

Function

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0008135	translation factor activity, nucleic acid binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006413	translational initiation

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1349431

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR009000 Translation protein, beta-barrel domain
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR015256 Translation initiation factor 2, gamma subunit, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03144
PF09173

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z0N1