Version 5.4
Mus musculus Gene: Triobp
Summary
InnateDB Gene IDBG-160440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Triobp
Gene Name TRIO and F-actin binding protein
Synonyms AI428493; EST478828; mKIAA1662; Tara
Species Mus musculus
Ensembl Gene ENSMUSG00000033088
Encoded Proteins
IDBP-261850
TRIO and F-actin binding protein
IDBP-261852
TRIO and F-actin binding protein
IDBP-261854
TRIO and F-actin binding protein
IDBP-261856
TRIO and F-actin binding protein
IDBP-542152
TRIO and F-actin binding protein
IDBP-531609
TRIO and F-actin binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78947724-79005867
Strand Forward strand
Band E1
Transcripts
ENSMUST00000109690 ENSMUSP00000105312
ENSMUST00000109689 ENSMUSP00000105311
ENSMUST00000109688 ENSMUSP00000105310
ENSMUST00000109687 ENSMUSP00000105309
ENSMUST00000140228
ENSMUST00000137934
ENSMUST00000130663 ENSMUSP00000122988
ENSMUST00000144151 ENSMUSP00000116765
ENSMUST00000129922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031625 ubiquitin protein ligase binding
GO:0051015 actin filament binding
Biological Process
GO:0007067 mitotic nuclear division
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0015629 actin cytoskeleton
GO:0030496 midbody
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100106
View Gene Order
ENSBTAG00000002539
Not yet available
Cross-References
SwissProt
TrEMBL G5E8W1 J9JI90
UniProt Splice Variant
Entrez Gene 110253
UniGene Mm.123714
RefSeq XM_006520291 NM_001024716 NM_001039155 NM_001039156 NM_138579 XM_006520284 XM_006520285 XM_006520286 XM_006520288 XM_006520289
OMIM
CCDS CCDS37136 CCDS37137 CCDS37138
HPRD
IMGT
MGI ID MGI:1349410
MGI Symbol Triobp
EMBL AL589670
GenPept
RNA Seq Atlas 110253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca