Version 5.4
Mus musculus Protein: Triobp
Summary
InnateDB Protein IDBP-261852.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Triobp
Protein Name TRIO and F-actin binding protein
Synonyms AI428493; EST478828; mKIAA1662; Tara;
Species Mus musculus
Ensembl Protein ENSMUSP00000105311
InnateDB Gene IDBG-160440 (Triobp)
Protein Structure
UniProt Annotation
Function May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to F-actin in a periodic pattern. {ECO:0000250}.Isoform 1: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Midbody {ECO:0000250}. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-445 and lasts from prophase to anaphase. At telophase, relocalizes to midbody (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031625 ubiquitin protein ligase binding
GO:0051015 actin filament binding
Biological Process
GO:0007067 mitotic nuclear division
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0015629 actin cytoskeleton
GO:0030496 midbody
Protein Structure and Domains
PDB ID MGI:1349410
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99KW3
PhosphoSite PhosphoSite-Q99KW3
TrEMBL J9JI90
UniProt Splice Variant
Entrez Gene 110253
UniGene Mm.123714
RefSeq NP_613045
MGI ID
MGI Symbol Triobp
OMIM
CCDS CCDS37137
HPRD
IMGT
EMBL AK053194 AK129417 AK170390 AL589670 BC003984 BC042760 BC053329 DQ228000 DQ228001 DQ228002 DQ278602
GenPept AAH03984 AAH42760 AAH53329 ABB59556 ABB59557 ABB59558 ABB77203 BAC35308 BAC98227 BAE41764

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca