InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbp1

Summary

InnateDB Gene

IDBG-160648.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbp1

Gene Name

fructose bisphosphatase 1

Synonyms

Fbp-2; Fbp2; Fbp3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000069805

Encoded Proteins

IDBP-160650

fructose bisphosphatase 1

IDBP-540194

fructose bisphosphatase 1

IDBP-539760

fructose bisphosphatase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165140:
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:62864753-62888282

Strand

Reverse strand

Band

Transcripts

ENSMUST00000092888	ENSMUSP00000090564
ENSMUST00000150013	ENSMUSP00000117146
ENSMUST00000134814	ENSMUSP00000115703

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016208	AMP binding
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006094	gluconeogenesis
GO:0006111	regulation of gluconeogenesis
GO:0016311	dephosphorylation
GO:0030308	negative regulation of cell growth
GO:0035690	cellular response to drug
GO:0045820	negative regulation of glycolytic process
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051289	protein homotetramerization
GO:0071286	cellular response to magnesium ion