InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ak1

Summary

InnateDB Gene

IDBG-160744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ak1

Gene Name

adenylate kinase 1

Synonyms

Ak-1; B430205N08Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026817

Encoded Proteins

IDBP-160746

adenylate kinase 1

IDBP-254225

adenylate kinase 1

IDBP-254227

adenylate kinase 1

IDBP-535849

adenylate kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106992:
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:32621758-32646805

Strand

Forward strand

Band

Transcripts

ENSMUST00000068271	ENSMUSP00000068479
ENSMUST00000113278	ENSMUSP00000108903
ENSMUST00000113277	ENSMUSP00000108902
ENSMUST00000156578	ENSMUSP00000123534
ENSMUST00000135392
ENSMUST00000127603

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0019205	nucleobase-containing compound kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006165	nucleoside diphosphate phosphorylation
GO:0007050	cell cycle arrest
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0016310	phosphorylation
GO:0046034	ATP metabolic process