InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fpgs

Summary

InnateDB Gene

IDBG-160952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fpgs

Gene Name

folylpolyglutamyl synthetase

Synonyms

AA408187

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009566

Encoded Proteins

IDBP-160954

folylpolyglutamyl synthetase

IDBP-537140

folylpolyglutamyl synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136877:
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:32682609-32704137

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028148	ENSMUSP00000028148
ENSMUST00000130164
ENSMUST00000132327
ENSMUST00000142186
ENSMUST00000123171
ENSMUST00000146498
ENSMUST00000156792
ENSMUST00000127812	ENSMUSP00000116434
ENSMUST00000149491
ENSMUST00000143743

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004326	tetrahydrofolylpolyglutamate synthase activity
GO:0005524	ATP binding
GO:0016874	ligase activity

Biological Process

GO:0001889	liver development
GO:0006730	one-carbon metabolic process
GO:0007420	brain development
GO:0009058	biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0031100	organ regeneration
GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process