InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fpgs

Summary

InnateDB Protein

IDBP-160954.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fpgs

Protein Name

folylpolyglutamyl synthetase

Synonyms

AA408187;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028148

InnateDB Gene

IDBG-160952 (Fpgs)

Protein Structure

UniProt Annotation

Function

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10-methylenetetrahydrofolate, 10- formyltetrahydrofolate and 5-formyltetrahydrofolate are the best substrates. Folic acid and 5-methyltetrahydrofolate can also act as substrates. {ECO:0000269PubMed:11772020, ECO:0000269PubMed:6548641}.

Subcellular Localization

Isoform 1: Mitochondrion inner membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}.Isoform 2: Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

With non-specific probe, highest content in kidney and liver and lowest in spleen, lung and small intestine, and readily detectable in all of the tumors except hepatoma. Isoform 1 and isoform 2 expressed in leukemic cells and isoform 4 and isoform 5 in liver cells. Isoform 1 and isoform 2 exclusively expressed in hepatoma and Lewis lung carcinoma. Isoform 1 and isoform 2 also expressed in bone marrow, small intestine and spleen. Kidney expresses isoform 1, isoform 2, isoform 4 and isoform 5. {ECO:0000269PubMed:10626793, ECO:0000269PubMed:17998333, ECO:0000269PubMed:9038166}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004326	tetrahydrofolylpolyglutamate synthase activity
GO:0005524	ATP binding
GO:0016874	ligase activity

Biological Process

GO:0001889	liver development
GO:0006730	one-carbon metabolic process
GO:0007420	brain development
GO:0009058	biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0031100	organ regeneration
GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process