InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndufa13

Summary

InnateDB Gene

IDBG-160997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufa13

Gene Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13

Synonyms

2700054G14Rik; AU022060; CDA016; CGI-39; GRIM-19; Grim19

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036199

Encoded Proteins

IDBP-260840

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 15753091

[Homo sapiens] YJEFN3 is a downstream effector of anti-bacterial function in intestinal epithelial cells that is required for NOD2-mediated NF-kappaB activation following NOD2 mediated recognition of bacterial muramyl dipeptide (MDP).

PMID 12163600

[Homo sapiens] YJEFN3 (NDUFA13) interacts with viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus and inhibits interferon/retinoic acid-induced cell death.

PMID 17928352

[Homo sapiens] YJEFN3 belongs to the family of genes associated with retinoid-interferon mortality and serves as an essential component of the oxidative phosphorylation system. YJEFN3 interacts with human herpesvirus 6B U95 protein and the resulting silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potential.

PMID 17823279

[Homo sapiens] YJEFN3 blocks SRC-induced gene expression through STAT3 and activation of cell adhesion molecules.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186010:
This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:69894188-69902558

Strand

Reverse strand

Band

B3.3

Transcripts

ENSMUST00000110167

ENSMUSP00000105796

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity

Biological Process

GO:0017148	negative regulation of translation
GO:0030262	apoptotic nuclear changes
GO:0030308	negative regulation of cell growth
GO:0045039	protein import into mitochondrial inner membrane
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process
GO:0097190	apoptotic signaling pathway
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005746	mitochondrial respiratory chain
GO:0005747	mitochondrial respiratory chain complex I
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome