InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndufa13

Summary

InnateDB Protein

IDBP-260840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufa13

Protein Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13

Synonyms

2700054G14Rik; AU022060; CDA016; CGI-39; GRIM-19; Grim19;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105796

InnateDB Gene

IDBG-160997 (Ndufa13)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000305PubMed:12628925}; Single-pass membrane protein {ECO:0000305PubMed:12628925}; Matrix side {ECO:0000305PubMed:12628925}. Nucleus {ECO:0000269PubMed:12628925}. Note=May be translocated into the nucleus upon IFN/RA treatment. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity

Biological Process

GO:0017148	negative regulation of translation
GO:0030262	apoptotic nuclear changes
GO:0030308	negative regulation of cell growth
GO:0045039	protein import into mitochondrial inner membrane
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process
GO:0097190	apoptotic signaling pathway
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005746	mitochondrial respiratory chain
GO:0005747	mitochondrial respiratory chain complex I
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome