Version 5.4
Homo sapiens Gene: LMNB2
Summary
InnateDB Gene IDBG-16103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMNB2
Gene Name lamin B2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176619
Encoded Proteins
IDBP-16105
lamin B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:2427638-2456996
Strand Reverse strand
Band p13.3
Transcripts
ENST00000325327 ENSP00000327054
ENST00000475819
ENST00000490554
ENST00000532465
ENST00000527409
ENST00000534495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 14 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005198 structural molecule activity
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005638 lamin filament
GO:0005882 intermediate filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062075
View Gene Order
ENSBTAG00000013624
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q03252
TrEMBL J9JID7
UniProt Splice Variant
Entrez Gene 84823
UniGene Hs.538286 Hs.621763 Hs.623611 Hs.742287
RefSeq NM_032737
HUGO HGNC:6638
OMIM 150341
CCDS CCDS12090
HPRD
IMGT
EMBL AC005624 AC011522 BC006551 BT007441 CH471139 M94362 M94363
GenPept AAA80979 AAB00873 AAC34573 AAH06551 AAP36109 EAW69378
RNA Seq Atlas 84823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca