Version 5.4
Mus musculus Gene: Lmnb2
Summary
InnateDB Gene IDBG-176482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lmnb2
Gene Name lamin B2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000062075
Encoded Proteins
IDBP-176484
lamin B2
IDBP-271100
lamin B2
IDBP-711750
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176619:
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80901203-80918245
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000057623 ENSMUSP00000057291
ENSMUST00000105332 ENSMUSP00000100969
ENSMUST00000159094
ENSMUST00000179022 ENSMUSP00000136524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005638 lamin filament
GO:0005882 intermediate filament
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000176619
View Gene Order
ENSBTAG00000013624
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P21619
TrEMBL Q3V159
UniProt Splice Variant
Entrez Gene 16907
UniGene Mm.408993 Mm.7362
RefSeq NM_010722
OMIM
CCDS CCDS24037
HPRD
IMGT
MGI ID MGI:96796
MGI Symbol Lmnb2
EMBL AK132671 BC042430 BC051985 D13455 X54098
GenPept AAH42430 AAH51985 BAA02708 BAE21293 CAA38032
RNA Seq Atlas 16907

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca