InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mmp14

Summary

InnateDB Gene

IDBG-161181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp14

Gene Name

matrix metallopeptidase 14 (membrane-inserted)

Synonyms

AI325305; MT-MMP-1; MT1-MMP; sabe

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000957

Encoded Proteins

IDBP-161183

matrix metallopeptidase 14 (membrane-inserted)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157227:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:54431604-54441258

Strand

Forward strand

Band

Transcripts

ENSMUST00000089688

ENSMUSP00000087119

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004222	metalloendopeptidase activity
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0016504	peptidase activator activity

Biological Process

GO:0001503	ossification
GO:0001525	angiogenesis
GO:0001541	ovarian follicle development
GO:0001666	response to hypoxia
GO:0001935	endothelial cell proliferation
GO:0001958	endochondral ossification
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0006979	response to oxidative stress
GO:0008584	male gonad development
GO:0009612	response to mechanical stimulus
GO:0009725	response to hormone
GO:0010952	positive regulation of peptidase activity
GO:0014070	response to organic cyclic compound
GO:0016477	cell migration
GO:0030307	positive regulation of cell growth
GO:0030324	lung development
GO:0030335	positive regulation of cell migration
GO:0030574	collagen catabolic process
GO:0031638	zymogen activation
GO:0035988	chondrocyte proliferation
GO:0043615	astrocyte cell migration
GO:0043627	response to estrogen
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048771	tissue remodeling
GO:0051895	negative regulation of focal adhesion assembly
GO:0060348	bone development
GO:0097094	craniofacial suture morphogenesis