Version 5.4
Mus musculus Gene: Map3k10
Summary
InnateDB Gene IDBG-161600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Map3k10
Gene Name mitogen-activated protein kinase kinase kinase 10
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040390
Encoded Proteins
IDBP-161602
mitogen-activated protein kinase kinase kinase 10
IDBP-264755
mitogen-activated protein kinase kinase kinase 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130758:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27656375-27674598
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000036453 ENSMUSP00000037725
ENSMUST00000108341 ENSMUSP00000103978
ENSMUST00000152032
ENSMUST00000133551
ENSMUST00000138243
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0043425 bHLH transcription factor binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007224 smoothened signaling pathway
GO:0008219 cell death
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043507 positive regulation of JUN kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000130758
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt Q66L42
TrEMBL
UniProt Splice Variant
Entrez Gene 269881
UniGene Mm.389883 Mm.397219
RefSeq XM_006540027 NM_001081292 NM_001290528
OMIM
CCDS CCDS39850
HPRD
IMGT
MGI ID MGI:1346879
MGI Symbol Map3k10
EMBL AC074312 BC046514 BC078445
GenPept AAH46514 AAH78445
RNA Seq Atlas 269881

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca