InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAP3K10

Summary

InnateDB Gene

IDBG-51212.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K10

Gene Name

mitogen-activated protein kinase kinase kinase 10

Synonyms

MEKK10; MLK2; MST

Species

Homo sapiens

Ensembl Gene

ENSG00000130758

Encoded Proteins

IDBP-51214

mitogen-activated protein kinase kinase kinase 10

IDBP-763708

IDBP-764714

IDBP-760072

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:40191744-40215575

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000253055	ENSP00000253055
ENST00000597986	ENSP00000471916
ENST00000593502	ENSP00000473021
ENST00000594951	ENSP00000471116
ENST00000601702
ENST00000594569
ENST00000594791
ENST00000593906

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004706	JUN kinase kinase kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0007254	JNK cascade
GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0008219	cell death
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043507	positive regulation of JUN kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000040390

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID NCI

p38_mkk3_6pathway

p38 MAPK signaling pathway

Cross-References

SwissProt

TrEMBL

M0R365

UniProt Splice Variant

Entrez Gene

4294

UniGene

Hs.466743

RefSeq

NM_002446 XM_006723222 XM_006723223

HUGO

HGNC:6849

OMIM

600137

CCDS

CCDS12549

HPRD

02533

IMGT

EMBL

AC011496 AC118344

GenPept

RNA Seq Atlas

4294