Version 5.4
| Mus musculus Gene: Ube2d1 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-161738.7 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Ube2d1 | ||||||||||||||||||||||
| Gene Name | ubiquitin-conjugating enzyme E2D 1 | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000019927 | ||||||||||||||||||||||
| Encoded Proteins |
ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog (yeast)
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072401:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 10:71254980-71285262 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | B5.3 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 235 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Cell Cycle, Mitotic pathway
Disease pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Separation of Sister Chromatids pathway
Cellular responses to stress pathway
Loss of Function of SMAD4 in Cancer pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Cellular response to hypoxia pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by BMP pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
M Phase pathway
Cell Cycle Checkpoints pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Loss of Function of TGFBR2 in Cancer pathway
Cellular Senescence pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Mitotic Metaphase and Anaphase pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Phosphorylation of the APC/C pathway
Toll-Like Receptors Cascades pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Gene Expression pathway
Loss of Function of TGFBR1 in Cancer pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Mitotic Spindle Checkpoint pathway
Generic Transcription Pathway pathway
MyD88-independent cascade pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Mitotic Anaphase pathway
Signaling by TGF-beta Receptor Complex pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
Loss of Function of SMAD2/3 in Cancer pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
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| KEGG |
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
TGF_beta_Receptor pathway
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| REACTOME |
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Phosphorylation of the APC/C pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Separation of Sister Chromatids pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Signaling by BMP pathway
Generic Transcription Pathway pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Cellular responses to stress pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Adaptive Immune System pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Mitotic Spindle Checkpoint pathway
Immune System pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Cellular response to hypoxia pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
TGFBR1 KD Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
Activated TLR4 signalling pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
Generic Transcription Pathway pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Activated TLR4 signalling pathway
Signaling by BMP pathway
M Phase pathway
MyD88-independent cascade pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Separation of Sister Chromatids pathway
Loss of Function of SMAD4 in Cancer pathway
IKK complex recruitment mediated by RIP1 pathway
Cellular responses to stress pathway
Loss of Function of TGFBR2 in Cancer pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Gene Expression pathway
Immune System pathway
Cell Cycle, Mitotic pathway
Phosphorylation of the APC/C pathway
Toll-Like Receptors Cascades pathway
Cell Cycle pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
Cellular Senescence pathway
Mitotic Spindle Checkpoint pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
Regulation of mitotic cell cycle pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
APC/C-mediated degradation of cell cycle proteins pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Innate Immune System pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell Cycle Checkpoints pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Cellular response to hypoxia pathway
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| KEGG |
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
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| INOH | |||||||||||||||||||||||
| PID NCI |
p53 pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.270530 Mm.408806 | ||||||||||||||||||||||
| RefSeq | NM_145420 XM_006513478 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS35933 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||