Version 5.4
Mus musculus Gene: Rfxank
Summary
InnateDB Gene IDBG-161750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rfxank
Gene Name regulatory factor X-associated ankyrin-containing protein
Synonyms Tvl1
Species Mus musculus
Ensembl Gene ENSMUSG00000036120
Encoded Proteins
IDBP-161752
regulatory factor X-associated ankyrin-containing protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064490:
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity. [provided by RefSeq, Jul 2008]
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:70130812-70139197
Strand Reverse strand
Band B3.3
Transcripts
ENSMUST00000075724 ENSMUSP00000075140
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007265 Ras protein signal transduction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000064490
View Gene Order
ENSBTAG00000001762
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04612
Antigen processing and presentation pathway
mmu05340
Primary immunodeficiency pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04612
Antigen processing and presentation pathway
hsa05340
Primary immunodeficiency pathway
INOH
PID NCI
hdac_classii_pathway
Signaling events mediated by HDAC Class II
Cross-References
SwissProt Q9Z205
TrEMBL Q53X17 Q543F0
UniProt Splice Variant
Entrez Gene 19727
UniGene Mm.161167
RefSeq NM_001025589 NM_011266
OMIM
CCDS CCDS22360
HPRD
IMGT
MGI ID MGI:1333865
MGI Symbol Rfxank
EMBL AF094761 AF123704 AK052298 BC010971 CH466569 L43164
GenPept AAC69884 AAD24798 AAH10971 AAL77617 BAC34924 EDL28785 EDL28787
RNA Seq Atlas 19727

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca